-
br Criteria for diagnosing of skeletal metastases
2021-03-03
Criteria for diagnosing of skeletal metastases by FDG PET/CT are increased standardized uptake value (SUV) on PET image, and osteo-blastic lesions, osteolytic lesions, mixed osteoblastic/osteolytic lesions, or no demonstrable anatomical change on CT image. Presence of Journal of Bone Oncology
-
br Contents lists avail iframe width height
2021-03-03
Contents lists available at ScienceDirect Chemical Engineering Journal journal homepage: www.elsevier.com/locate/cej Black phosphorus nanosheets-based stable drug delivery system via drug- T self-stabilization for combined photothermal and chemo cancer therapy Gan Liua,b, Hsiang-I Tsa
-
br Fig Penetration of G PAMAM dendrimer
2021-03-03
Fig. 6. Penetration of G4 PAMAM dendrimer conjugates in multicellular spheroids at various depths after 1 h and 4 h incubation captured as Z-stacks by confocal microscopy. Fig. 7. Quantitative assessment of cellular uptake in multicellular tumor spheroids treated with F-G4-PEG and F-G4-PEG-Biot
-
br Schrader et al demonstrated that
2020-08-30
Schrader et al. [52] demonstrated that vimentin expression was upregulated with increasing stiffness of substrate. So far, the in-duction of EMT is believed to promote tumor cell motility and in-vasion. In another study, Tsuji et al. [53] reported collective migration for the role of EMT in cancer
-
br caption on next page br Fig CD
2020-08-30
(caption on next page) Fig. 1. CD90 is upregulated in pancreatic cancer. (A) Relative mRNA level of CD90 in the pancreas is shown. Data were collected from TCGA (PAAD), GSE15471, GSE28375 and GSE102238 (Renji cohort) (mean ± SEM, unpaired two-tailed Student's t-test). (B) Representative immunoh
-
br Introduction br Lung cancer is a severe illness derived
2020-08-30
1. Introduction Lung cancer is a severe illness derived from malignant tumor de-veloped in the respiratory epithelium (bronchi, bronchioles, and al-veoli) [1] and in 2018 it was marked as the most common cancer worldwide (2.09 million cases), having the greatest number of cancer deaths (1.76 mi
-
br Similarly PHPMA was functionalized with Cy acceptor
2020-08-30
Similarly, PHPMA was functionalized with Cy5 (acceptor fluorophore) and Cy3 (donor fluorophore) or epirubicin (EPI) through a GFLG linker Fig. 22. Schematic structure of PHPMA functionalized by Cy5 and EPI for further FRET-monitoring of the EPI release mediated by Cathepsin B. Adapted with perm
-
br Among the different pathologies Cathepsins
2020-08-28
Among the different pathologies, Cathepsins have been largely employed as leverage to treat cancer from various Cathepsin-sensitive drug delivery systems because of its overexpression at the tumor sites. For instance, cysteine proteases have increased activity as well as aberrant localization with
-
br Involvement of Notch receptors in tumors
2020-08-28
Involvement of Notch receptors in tumors has been previously described in several types of cancer, where Notch receptors serve as oncogenes or tumor suppressors [5]. Notch3, in particular, is overexpressed by breast cancer Doxorubicinol [8] whereby down-regulation of Notch3 leads to reduced proli
-
Fig Silencing cystathionine synthase CBS protein
2020-08-28
Fig. 5. Silencing cystathionine β-synthase (CBS) protein expression attenuates cisplatin resistance in cisplatin-resistant ovarian cancer cell lines OVcisR and SKVcisR. (a) Immunoblot for CBS of 20 μg whole cell lysate to measure efficacy of lentiviral-mediated gene silencing of CBS. Blots are re
-
br Analysis of tumor growth br Luciferase
2020-08-28
5.9. Analysis of tumor growth Luciferase-positive GBM tumors were imaged using an In Vivo Imaging System (IVIS) Spectrum (Caliper Life Sciences) and analyzed using Living Image® software (PerkinElmer). Animals were injected intraperitoneally with 4.5 mg D-luciferin potassium salt (GoldBio) in 1
-
br Chemotherapy br metastatic recurrences even after
2020-08-28
Chemotherapy metastatic recurrences even after these postoperative adjuvant che-motherapies, especially in those with pathological stage III disease [7]. NAC, or perioperative chemotherapy (POC), consisting of three courses of ECF (epirubicin/cisplatin/infusional 5-FU) combined with surgery and
-
br year old man poorly differentiated
2020-08-28
1562 1: 80-year-old man, poorly differentiated adenocarcinoma; 1563 case 2: 51-year-old man, poorly differentiated adenocarci- 1565 adenocarcinoma) were obtained from ReproCELL Incorpo- 1566 rated (Yokohama, Japan). Human early gastric adenocarci- 1567 noma tissue specimens were obtain
-
Remdesivir br terminal HSP inhibitor and
2020-08-28
terminal HSP90 inhibitor and demonstrated that it possesses strong anti-tumor activity in non-small cell lung cancer (NSCLC) via HIF-1α degradation mediated by the ubiquitin-proteasome pathway [25]. In the present study, we sought to investigate the mechanism of action of L80 responsible for its n
-
br P plays an important role in
2020-08-28
P53 plays an important role in a variety of life activities, including apoptosis (Lopes et al., 2018; Mantovani et al., 2017). To investigate the effect of buforin IIb on p53 function, we firstly examined the mRNA and protein level of p53. As shown in Fig. 3A, the transcriptional ac-tivity of p53 a